Article
p53 protein and Ki-67 overexpression in urothelial dysplasia of bladder.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Dec 2002
Sun Wei, Zhang Ping L, Herrera Guillermo A
Abstract excerpt
Mutated tumor suppression gene p53 is a common genetic abnormality in most papillary or invasive transitional cell carcinomas (TCC). In these cases, overexpression of p53 protein is detectable in nuclei by immunohistochemical methods. Nuclear antigen Ki-67, a marker of cellular proliferation, has been shown to correlate with the growth of many human neoplasms, including TCC. Since overexpression of p53 protein...
Topics
- Carcinoma in Situ
- Carcinoma, Transitional Cell
- Genes, p53
- Humans
- Immunohistochemistry
- Ki-67 Antigen
- Mutation
- Tumor Suppressor Protein p53
- Urinary Bladder
- Urinary Bladder Neoplasms
- Urothelium