Article
[p53 in urogenital tumors:analysis of expression and mutation].
Verhandlungen der Deutschen Gesellschaft fur Pathologie - 1 Jan 1993
Löning T, Schlechte H, Friedrichs K, Schnoor D, Ditscherlein G, Bommer G, Löning S
Abstract excerpt
DNA and paraffin material of more than 100 tumors of prostate, bladder and female genital organs were analyzed for p53 aberrations and compared with normal tissues by immunohistochemistry, PCR of p53 exons 5-8 and TGGE. While normal tissues, precancerous and borderline lesions, and well differentiated carcinomas usually showed wild type p53 and negative immunostaining, high grade and/or high stage carcinomas...
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