Article
Analysis of p53 tumor suppressor gene mutations and human papillomavirus infection in human bladder cancers.
Yonsei medical journal - 1 Sept 1995
Kim K H, Kim Y S
Abstract excerpt
To determine whether the dysfunction of p53 caused either by mutation of the p53 gene itself or by binding to E6 protein of oncogenic HPVs is involved in the transitional cell carcinomas (TCCs) of the bladder, we analyzed 23 TCCs of the bladder. DNA was extracted from each paraffin embedded tissue of TCCs of bladder and polymerase chain reaction (PCR)/single strand conformation polymorphism (SSCP) analysis were...
Topics
- Base Sequence
- Coloring Agents
- Genes, Tumor Suppressor
- Genes, p53
- Humans
- Immunohistochemistry
- Molecular Probes
- Molecular Sequence Data
- Mutation
- Papillomaviridae
- Papillomavirus Infections