Steady-state plasma concentrations of propafenone--chirality and metabolism.

Article

Steady-state plasma concentrations of propafenone--chirality and metabolism.

International journal of clinical pharmacology and therapeutics - 1 Jul 1994

Volz M, Mitrovic V, Schlepper M

Abstract excerpt

In a selected group of 86 patients (60 males, 26 females) with symptomatic ventricular arrhythmias, possible interactions between metabolic and chiral effects at steady-state were investigated by comparing the plasma levels of propafenone, its major metabolites and the 2 structural isomers. The a...

Topics

Adult
Aged
Arrhythmias, Cardiac
Delayed-Action Preparations
Double-Blind Method
Female
Humans
Male
Middle Aged
Phenotype
Propafenone
Stereoisomerism

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.