Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Steady-state plasma concentrations of propafenone--chirality and metabolism.

International journal of clinical pharmacology and therapeutics - 1 Jul 1994

Volz M, Mitrovic V, Schlepper M

Abstract excerpt

In a selected group of 86 patients (60 males, 26 females) with symptomatic ventricular arrhythmias, possible interactions between metabolic and chiral effects at steady-state were investigated by comparing the plasma levels of propafenone, its major metabolites and the 2 structural isomers. The antiarrhythmic drug propafenone is metabolized--besides a minor dealkylation pathway--mainly via 5-hydroxylation. It is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Arrhythmias, Cardiac
Share to Double-Blind Method

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phenotype

Share to Stereoisomerism

Source

Identifiers

PMID: 7952800

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Steady-state plasma concentrations of propafenone--chirality and metabolism.PMID 7952800Read ↗

Steady-state plasma kinetics of slow-release propafenone, its two isomers and its main metabolites.Semantic proximity Read ↗

Minimal effective concentration values of propafenone and 5-hydroxy-propafenone in acute and chronic therapy.Semantic proximity Read ↗

Propafenone in a usual dose produces severe side-effects: the impact of genetically determined metabolic status on drug therapy.Semantic proximity Read ↗

[Determination of oxidative phenotype in a sample population and correlation with the pharmacokinetics of propafenone].Semantic proximity Read ↗

CYP2D6 phenotype determines pharmacokinetic variability of propafenone enantiomers in 16 HAN Chinese subjects.Semantic proximity Read ↗

Quinidine-enhanced beta-blockade during treatment with propafenone in extensive metabolizer human subjects.Semantic proximity Read ↗

Use of a propafenone metabolic ratio as a measure of CYP2D6 activity.Semantic proximity Read ↗

The role of genetically determined polymorphic drug metabolism in the beta-blockade produced by propafenone.Semantic proximity Read ↗

Enantioselectivity in the steady-state pharmacokinetics of metoprolol in hypertensive patients.Semantic proximity Read ↗

Effect of CYP2D6 genetic polymorphism on peak propafenone concentration: no significant effect of CYP2D6*10.Semantic proximity Read ↗

The pharmacokinetic and pharmacodynamic interaction between propafenone and lidocaine.Semantic proximity Read ↗

Debrisoquine phenotype and the pharmacokinetics and beta-2 receptor pharmacodynamics of metoprolol and its enantiomers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.