Article
The role of genetically determined polymorphic drug metabolism in the beta-blockade produced by propafenone.
The New England journal of medicine - 21 Jun 1990
Lee J T, Kroemer H K, Silberstein D J, Funck-Brentano C, Lineberry M D, Wood A J, Roden D M, Woosley R L
Abstract excerpt
Propranolol and the sodium-channel-blocking antiarrhythmic agent propafenone share structural features. Although propafenone's beta-blocking actions are readily demonstrable in vitro, clinically significant beta-blockade occurs inconsistently in vivo. In this study, we tested the hypothesis that...
Topics
- Adrenergic beta-Antagonists
- Adult
- Biotransformation
- Female
- Heart Rate
- Humans
- Hydroxylation
- Individuality
- Male
- Phenotype
- Polymorphism, Genetic
- Propafenone
- Receptors, Adrenergic, beta