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Article

The role of genetically determined polymorphic drug metabolism in the beta-blockade produced by propafenone.

The New England journal of medicine - 21 Jun 1990

Lee J T, Kroemer H K, Silberstein D J, Funck-Brentano C, Lineberry M D, Wood A J, Roden D M, Woosley R L

Abstract excerpt

Propranolol and the sodium-channel-blocking antiarrhythmic agent propafenone share structural features. Although propafenone's beta-blocking actions are readily demonstrable in vitro, clinically significant beta-blockade occurs inconsistently in vivo. In this study, we tested the hypothesis that genetically determined variations in the biotransformation of propafenone to its 5-hydroxy metabolite account for...

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Share to Adrenergic beta-Antagonists
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 1971708
DOI: 10.1056/NEJM199006213222502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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