Article
Enantioselectivity in the steady-state pharmacokinetics of metoprolol in hypertensive patients.
Chirality - 1 Jan 1999
Cerqueira P M, Cesarino E J, Mateus F H, Mere Y, Santos S R, Lanchote V L
Abstract excerpt
In the present study we investigated the enantioselectivity in the pharmacokinetics of metoprolol administered in a multiple-dose regimen as the racemate. The study was conducted on 10 patients of both sexes with mild to severe essential hypertension, aged 28 to 76 years, with normal hepatic and renal function and phenotyped as extensive metabolizers of debrisoquine (urine debrisoquine to 4-hydroxydebrisoquine...
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