Article
The pharmacokinetic and pharmacodynamic interaction between propafenone and lidocaine.
Clinical pharmacology and therapeutics - 1 Jan 1993
Ujhelyi M R, O'Rangers E A, Fan C, Kluger J, Pharand C, Chow M S
Abstract excerpt
Although propafenone is a known substrate and inhibitor of the cytochrome P450 4-hydroxylation pathway of debrisoquin (CYP2D6 isozyme), its effects on other hepatic mixed- function oxidative isozymes have not been extensively evaluated. We studied the influence of propafenone on the disposition o...
Topics
- Adult
- Blood Pressure
- Drug Interactions
- Electrocardiography
- Humans
- Infusions, Intravenous
- Lidocaine
- Male
- Phenotype
- Propafenone
- Random Allocation
- Regression Analysis