Article
Propafenone in a usual dose produces severe side-effects: the impact of genetically determined metabolic status on drug therapy.
Journal of internal medicine - 1 Nov 1995
Mörike K, Magadum S, Mettang T, Griese E U, Machleidt C, Kuhlmann U
Abstract excerpt
We report the case of an elderly lady presenting with dizziness, a head injury resulting from a fall and bradycardia. Propafenone 150 mg t.i.d. had been prescribed for atrial fibrillation with tachyarrhythmia, induced by hyperthyroidism, 18 months earlier. A toxic concentration of parent propafen...
Topics
- Aged
- Anti-Arrhythmia Agents
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Female
- Genotype
- Humans
- Phenotype
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Propafenone
- Sparteine
- Time Factors