Article
Minimal effective concentration values of propafenone and 5-hydroxy-propafenone in acute and chronic therapy.
Cardiovascular drugs and therapy - 1 Feb 1990
Capucci A, Boriani G, Marchesini B, Strocchi E, Tomasi L, Balducelli M, Frabetti L, Ambrosioni E, Magnani B
Abstract excerpt
We evaluated the antiarrhythmic efficacy and the minimal effective concentrations of propafenone and its metabolite 5-hydroxy-propafenone during a) acute intravenous infusion (1.5 mg/kg in bolus followed by 45 minutes infusion), b) an acute oral single-dose test (450 mg), and c) 14-day chronic th...
Topics
- Administration, Oral
- Adult
- Aged
- Debrisoquin
- Dose-Response Relationship, Drug
- Electrocardiography
- Female
- Humans
- Infusions, Intravenous
- Male
- Middle Aged
- Phenotype