Article
[Determination of oxidative phenotype in a sample population and correlation with the pharmacokinetics of propafenone].
Cardiologia (Rome, Italy) - 1 Feb 1990
Boriani G, Strocchi E, Capucci A, Boschi S, Frabetti L, Ambrosioni E, Magnani B
Abstract excerpt
UNLABELLED: Propafenone, like other cardioactive drugs (metoprolol, propranolol, encainide) is submitted to oxidative metabolism, evaluable by assessment of debrisoquine oxidative capacity. Two phenotypes have been described: extensive and poor oxidizers, with interethnic differences in the prevalence of poor oxidizers. Aims of this study were: 1) to assess the oxidative phenotype in a sample of the Italian...
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