[Determination of oxidative phenotype in a sample population and correlation with the pharmacokinetics of propafenone].

Article

[Determination of oxidative phenotype in a sample population and correlation with the pharmacokinetics of propafenone].

Cardiologia (Rome, Italy) - 1 Feb 1990

Boriani G, Strocchi E, Capucci A, Boschi S, Frabetti L, Ambrosioni E, Magnani B

Abstract excerpt

UNLABELLED: Propafenone, like other cardioactive drugs (metoprolol, propranolol, encainide) is submitted to oxidative metabolism, evaluable by assessment of debrisoquine oxidative capacity. Two phenotypes have been described: extensive and poor oxidizers, with interethnic differences in the preva...

Topics

Adult
Aged
Debrisoquin
Humans
Italy
Middle Aged
Oxidation-Reduction
Phenotype
Propafenone

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