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Article

Use of a propafenone metabolic ratio as a measure of CYP2D6 activity.

International journal of clinical pharmacology and therapeutics - 1 Sept 2000

Anzenbacherová E, Anzenbacher P, Perlik F, Kvetina J

Abstract excerpt

AIM: The antiarrythmic drug propafenone is metabolized to its main metabolite by CYP2D6, suggesting that its metabolic ratio may be used for CYP2D6 phenotyping. However, reported ratios obtained from plasma concentrations did not reflect the phenotype. The objective of this paper was to find optimal conditions for plasma sampling based on pharmacokinetic data and to investigate whether propafenone/metabolite...

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Identifiers

PMID: 11020029
DOI: 10.5414/cpp38426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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