Article
Screening for hydroxylation and acetylation polymorphisms in man via simultaneous analysis of urinary metabolites of mephenytoin, dextromethorphan and caffeine by capillary electrophoretic procedures.
Journal of chromatography. B, Biomedical applications - 3 Jun 1994
Caslavska J, Hufschmid E, Theurillat R, Desiderio C, Wolfisberg H, Thormann W
Abstract excerpt
Phenotypes for hydroxylation can be predicted by using mephenytoin and dextromethorphan as substrates, whereas phenotypes for acetylation can be determined with caffeine as probe drug. After single-dose administration of one of these drugs, of two of them simultaneously, or of the three drugs tog...
Topics
- Acetylation
- Adult
- Biotransformation
- Caffeine
- Chromatography, High Pressure Liquid
- Dextromethorphan
- Electrophoresis, Polyacrylamide Gel
- Humans
- Hydroxylation
- Mephenytoin
- Middle Aged
- Phenotype
- Polymorphism, Genetic