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Article

Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.

Cancer research - 1 Apr 2011

Adams Jessica R, Xu Keli, Liu Jeff C, Agamez Natalia M Ruiz, Loch Amanda J, Wong Ruth G, Wang Wei, Wright Katherine L, Lane Timothy F, Zacksenhaus Eldad, Egan Sean E

Abstract excerpt

PIK3CA, which codes for the p110α catalytic subunit of phosphatidylinositol 3-kinase, is one of the most frequently mutated genes in human breast cancer. Here, we describe a mouse model for PIK3CA-induced breast cancer by using the ROSA26 (R26) knock-in system, in which targeted Pik3ca alleles can be activated through transgenic expression of Cre recombinase. We mated Pik3ca(H1047R) and Pik3ca(wt) knock-in lines...

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Identifiers

PMID: 21324922
DOI: 10.1158/0008-5472.CAN-10-0738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.PMID 21324922Read ↗

Conditional activation of Pik3ca(H1047R) in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations.Semantic proximity Read ↗

Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors.Semantic proximity Read ↗

S100a4 upregulation in Pik3caH1047R;Trp53R270H;MMTV-Cre-driven mammary tumors promotes metastasis.Semantic proximity Read ↗

Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047RSemantic proximity Read ↗

Inhibitors of STAT3, β-catenin, and IGF-1R sensitize mouse PIK3CA-mutant breast cancer to PI3K inhibitors.Semantic proximity Read ↗

Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies.Semantic proximity Read ↗

Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapiesSemantic proximity Read ↗

Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms.Semantic proximity Read ↗

Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity.Semantic proximity Read ↗

Genetically engineered mouse models of PI3K signaling in breast cancerSemantic proximity Read ↗

PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours.Semantic proximity Read ↗

Elevated PI3K signaling drives multiple Breast Cancer subtypesSemantic proximity Read ↗

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