Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of ANC-1 in tethering nuclei to the actin cytoskeleton.

Science (New York, N.Y.) - 11 Oct 2002

Starr Daniel A, Han Min

Abstract excerpt

Mutations in anc-1 (nuclear anchorage defective) disrupt the positioning of nuclei and mitochondria in Caenorhabditis elegans. ANC-1 is shown to consist of mostly coiled regions with a nuclear envelope localization domain (called the KASH domain) and an actin-binding domain; this structure was conserved with the Drosophila protein Msp-300 and the mammalian Syne proteins. Antibodies against ANC-1 localized...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Animals, Genetically Modified
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoplasm

Share to Cytoskeleton

Share to Genes, Helminth

Share to Microfilament Proteins

Share to Nuclear Envelope

Source

Identifiers

PMID: 12169658
DOI: 10.1126/science.1075119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of ANC-1 in tethering nuclei to the actin cytoskeleton.PMID 12169658Read ↗

UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development.Semantic proximity Read ↗

The Nesprin family member ANC-1 regulates synapse formation and axon termination by functioning in a pathway with RPM-1 and β-Catenin.Semantic proximity Read ↗

The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis.Semantic proximity Read ↗

Molecular characterization of the Caenorhabditis elegans ALP/Enigma gene alp‐1Semantic proximity Read ↗

The Drosophila KASH domain proteins Msp-300 and Klarsicht and the SUN domain protein Klaroid have no essential function during oogenesis.Semantic proximity Read ↗

Gene Expression Modulation by the Linker of Nucleoskeleton and Cytoskeleton Complex Contributes to ProteostasisSemantic proximity Read ↗

On the roles of the Drosophila KASH domain proteins Msp-300 and Klarsicht.Semantic proximity Read ↗

Drosophila klaroid encodes a SUN domain protein required for Klarsicht localization to the nuclear envelope and nuclear migration in the eye.Semantic proximity Read ↗

Drosophila klarsicht has distinct subcellular localization domains for nuclear envelope and microtubule localization in the eye.Semantic proximity Read ↗

toca-1 is in a novel pathway that functions in parallel with a SUN-KASH nuclear envelope bridge to move nuclei in Caenorhabditis elegans.Semantic proximity Read ↗

The ALP-Enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans.Semantic proximity Read ↗

Neural maintenance roles for the matrix receptor dystroglycan and the nuclear anchorage complex in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.