Inhibition of CYP2D6 activity by treatment with propranolol and the role of 4-hydroxy propranolol.

doi:10.1111/j.1365-2125.1994.tb04315.x

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Article

Inhibition of CYP2D6 activity by treatment with propranolol and the role of 4-hydroxy propranolol.

British journal of clinical pharmacology - 1 Jul 1994

Rowland K, Yeo W W, Ellis S W, Chadwick I G, Haq I, Lennard M S, Jackson P R, Ramsay L E, Tucker G T

Abstract excerpt

1. The 4-hydroxylation of propranolol by rat and human liver microsomes is associated with formation of a chemically reactive species which binds irreversibly to cytochrome P4502D6 (CYP2D6) destroying its catalytic function. Therefore, the effect of propranolol treatment (80 mg twice daily) on debrisoquine phenotype was examined, to see if it resulted in phenocopying in vivo. The role of 4-hydroxypropranolol...

Topics

Adult
Aged
Chromatography, High Pressure Liquid
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System
Debrisoquin
Female
Humans
Male
Metoprolol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microsomes, Liver

Middle Aged

Mixed Function Oxygenases

Phenotype

Propranolol

Recombinant Proteins

Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 7946944
DOI: 10.1111/j.1365-2125.1994.tb04315.x
PMCID: PMC1364831

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7946944-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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