Article
Propranolol oxidation by human liver microsomes--the use of cumene hydroperoxide to probe isoenzyme specificity and regio- and stereoselectivity.
British journal of clinical pharmacology - 1 Nov 1990
Otton S V, Gillam E M, Lennard M S, Tucker G T, Woods H F
Abstract excerpt
1. Three oxidations of the enantiomers of propranolol were studied in human liver microsomes under two reaction conditions. Previous in vitro studies had established that two of the livers were from poor metaboliser (PM) phenotypes for the debrisoquine 4-hydroxylase (cytochrome P-450IID6) and the...
Topics
- Benzene Derivatives
- Humans
- Hydroxylation
- Isoenzymes
- Microsomes, Liver
- Oxidation-Reduction
- Phenotype
- Propranolol
- Stereoisomerism
- Substrate Specificity