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Article

Identification of the <i>ron</i> Gene Product as the Receptor for the Human Macrophage Stimulating Protein

7 Oct 1994

Abstract excerpt

Macrophage-stimulating protein (MSP) is a member of the hepatocyte growth factor-scatter factor (HGF-SF) family. Labeled MSP bound to Madin-Darby canine kidney (MDCK) cells transfected with complementary DNA encoding Ron, a cell membrane protein tyrosine kinase. Cross-linking of 125I-labeled MSP to transfected cells (MDCK-RE7 cells) and immunoprecipitation by antibodies to Ron revealed a 220-kilodalton complex, a...

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PMID: 7939629
DOI: 10.1126/science.7939629

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Related research

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Research trail→

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Identification of the <i>ron</i> Gene Product as the Receptor for the Human Macrophage Stimulating ProteinPMID 7939629Read ↗

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Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor.Semantic proximity Read ↗

Point mutations and overexpression of Ron induce transformation, tumor formation, and metastasis.Semantic proximity Read ↗

Restricted expression of the ron gene encoding the macrophage stimulating protein receptor during mouse developmentSemantic proximity Read ↗

Point mutations in the tyrosine kinase domain release the oncogenic and metastatic potential of the Ron receptor.Semantic proximity Read ↗

The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma.Semantic proximity Read ↗

A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype.Semantic proximity Read ↗

Alterations in a defined extracellular region of the RON receptor tyrosine kinase promote RON-mediated motile and invasive phenotypes in epithelial cells.Semantic proximity Read ↗

STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family.Semantic proximity Read ↗

A novel variant of the RON receptor tyrosine kinase derived from colorectal carcinoma cells which lacks tyrosine phosphorylation but induces cell migration.Semantic proximity Read ↗

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