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Article

Point mutations and overexpression of Ron induce transformation, tumor formation, and metastasis.

Oncogene - 27 Sept 2001

Peace B E, Hughes M J, Degen S J, Waltz S E

Abstract excerpt

The receptor tyrosine kinase Ron is a member of the receptor family that includes the proto-oncogene Met and the avian oncogene Sea. The interaction of Ron with its ligand, known as hepatocyte growth factor-like protein (HGFL) or macrophage stimulating protein (MSP), induces crucial cellular responses including invasive growth, proliferation, cell scattering, and branching morphogenesis. Based on the homology and...

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Source

Identifiers

PMID: 11593422
DOI: 10.1038/sj.onc.1204836

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Point mutations and overexpression of Ron induce transformation, tumor formation, and metastasis.PMID 11593422Read ↗

Oncogenesis of RON receptor tyrosine kinase: a molecular target for malignant epithelial cancers.Semantic proximity Read ↗

Point mutations in the tyrosine kinase domain release the oncogenic and metastatic potential of the Ron receptor.Semantic proximity Read ↗

An Introduction and Overview of RON Receptor Tyrosine Kinase SignalingSemantic proximity Read ↗

Constitutive Activation of the RON Gene Promotes Invasive Growth but Not TransformationSemantic proximity Read ↗

Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor.Semantic proximity Read ↗

Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addictionSemantic proximity Read ↗

From Concept to Reality: The Long Road to c-Met and RON Receptor Tyrosine Kinase Inhibitors for the Treatment of CancerSemantic proximity Read ↗

The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitro.Semantic proximity Read ↗

Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunitiesSemantic proximity Read ↗

STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family.Semantic proximity Read ↗

Role of c-MET in upper aerodigestive malignancies--from biology to novel therapies.Semantic proximity Read ↗

Oncogenic Mutants of RON and MET Receptor Tyrosine Kinases Cause Activation of the β-Catenin PathwaySemantic proximity Read ↗

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