Genetic influences on locomotor activating effects of ethanol and sodium pentobarbital.

doi:10.1016/0091-3057(94)90319-0

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Article

Genetic influences on locomotor activating effects of ethanol and sodium pentobarbital.

Pharmacology, biochemistry, and behavior - 1 Jul 1994

Dudek B C, Tritto T, Underwood K A

Abstract excerpt

The paradoxical capability of sedative-hypnotics to produce behavioral disinhibition varies among genotypes. In DBA/2 mice ethanol (ETOH) produced strong locomotor stimulation with the peak of the biphasic curve at 1.5 g/kg IP. C57BL/6 mice showed no activation, and F1S were intermediate. These c...

Topics

Animals
Dose-Response Relationship, Drug
Ethanol
Female
Genotype
Male
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Motor Activity
Pentobarbital
Postural Balance
Reflex
Sleep
Species Specificity

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