Transgenic mice with elevated level of CuZnSOD are highly susceptible to malaria infection.

doi:10.1016/s0891-5849(98)00026-4

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Article

Transgenic mice with elevated level of CuZnSOD are highly susceptible to malaria infection.

Free radical biology & medicine - 1 Jun 1998

Golenser J, Peled-Kamar M, Schwartz E, Friedman I, Groner Y, Pollack Y

Abstract excerpt

Copper/zinc superoxide dismutase (CuZnSOD) catalyses the conversion of O2.- into H2O2. Constitutive overexpression of CuZnSOD in cells and animals creates an indigenous oxidative stress that predisposes them to added insults. In this study, we used transgenic CuZnSOD (Tg-CuZnSOD) mice with elevat...

Topics

Animals
Ascorbic Acid
Enzyme Activation
Erythrocytes
Female
Genetic Predisposition to Disease
Humans
Hypoxanthine
Malaria
Male
Mice
Mice, Inbred BALB C
Mice, Transgenic
Oxidative Stress
Plasmodium berghei
Reactive Oxygen Species
Superoxide Dismutase

Source

Open in PubMed

Identifiers

PMID: 9641269
DOI: 10.1016/s0891-5849(98)00026-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9641269-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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