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Enhanced Diabetes-Induced Cataract in Copper-Zinc Superoxide Dismutase–Null Mice

26 May 2009

Abstract excerpt

PURPOSE: Oxidative stress is thought to contribute to diabetes-induced cataract, and the authors have previously demonstrated that lenses from mice lacking the antioxidant enzyme copper-zinc superoxide dismutase (SOD1) show elevated levels of superoxide radicals and are more prone in vitro to develop glucose-induced cataract than are wild-type lenses. In the present study the effect of streptozotocin-induced...

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PMID: 19324844
DOI: 10.1167/iovs.09-3510

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