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Article

Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22.

Molecular and cellular biology - 1 Nov 1994

Ono Y, Ohno M, Shimura Y

Abstract excerpt

In the budding yeast Saccharomyces cerevisiae, a number of PRP genes known to be involved in pre-mRNA processing have been genetically identified and cloned. Three PRP genes (PRP2, PRP16, and PRP22) were shown to encode putative RNA helicases of the family of proteins with DEAH boxes. However, any such splicing factor containing the helicase motifs in vertebrates has not been identified. To identify human...

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Identifiers

PMID: 7935475
DOI: 10.1128/mcb.14.11.7611-7620.1994
PMCID: PMC359297

Genes

HRH1

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22.PMID 7935475Read ↗

Prp43: An RNA helicase-like factor involved in spliceosome disassembly.Semantic proximity Read ↗

The first ATPase domain of the yeast 246-kDa protein is required for in vivo unwinding of the U4/U6 duplex.Semantic proximity Read ↗

Interaction between a G-patch protein and a spliceosomal DEXD/H-box ATPase that is critical for splicing.Semantic proximity Read ↗

A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family.Semantic proximity Read ↗

The DEAH-box protein PRP22 is an ATPase that mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes.Semantic proximity Read ↗

Motifs IV and V in the DEAH box splicing factor Prp22 are important for RNA unwinding, and helicase-defective Prp22 mutants are suppressed by Prp8.Semantic proximity Read ↗

Dominant negative mutants of the yeast splicing factor Prp2 map to a putative cleft region in the helicase domain of DExD/H-box proteins.Semantic proximity Read ↗

Brr2p carboxy-terminal Sec63 domain modulates Prp16 splicing RNA helicase.Semantic proximity Read ↗

A suppressor of a yeast splicing mutation (prp8-1) encodes a putative ATP-dependent RNA helicase.Semantic proximity Read ↗

The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome.Semantic proximity Read ↗

Mutational analysis of the RNA helicase Dhh1 in Ste12 expression and yeast mating.Semantic proximity Read ↗

Four yeast spliceosomal proteins (PRP5, PRP9, PRP11, and PRP21) interact to promote U2 snRNP binding to pre-mRNA.Semantic proximity Read ↗

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