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Article

p190B RhoGAP regulates endothelial-cell-associated proteolysis through MT1-MMP and MMP2

28 May 2008

Abstract excerpt

The two isoforms of p190 RhoGAP (p190A and p190B) are important regulators of RhoGTPase activity in mammalian cells. Both proteins are ubiquitously expressed, are involved in the same signalling pathways and interact with the same identified binding partners. In search of isoform functional specificity, we knocked down the expression of each p190 protein using siRNA and examined the resulting phenotypic changes...

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PMID: 18505793
DOI: 10.1242/jcs.025817

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