Genotype-specific blockade of cocaine-induced weight loss by the protein synthesis inhibitor, anisomycin.

Abstract excerpt

Cocaine has been shown to reduce food intake and body weight in rodents and humans. The results of recent research suggest that de novo protein synthesis in the brain is associated with neuroadaptive changes in the central nervous system. The present study reports the effect of anisomycin, a protein synthesis inhibitor with limited toxicity, on the reduction in body weight resulting from repeated daily injections...

Topics

• Animals
• Anisomycin
• Body Weight
• Cocaine
• Genotype
• Male
• Mice
• Mice, Inbred Strains
• Species Specificity
• Weight Loss