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Article

Substrate requirements of hepatitis C virus serine proteinase for intermolecular polypeptide cleavage in Escherichia coli.

Journal of virology - 1 Nov 1994

Komoda Y, Hijikata M, Sato S, Asabe S, Kimura K, Shimotohno K

Abstract excerpt

Using as substrates a series of chimeric proteins containing various fragments of the hepatitis C virus precursor polyprotein between Escherichia coli maltose binding protein and dihydrofolate reductase, we analyzed the substrate requirements of hepatitis C viral serine proteinase (Cpro-2) for intermolecular polypeptide cleavage in E. coli. Cpro-2-dependent substrate cleavage was observed in E. coli cells...

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Identifiers

PMID: 7933118
DOI: 10.1128/JVI.68.11.7351-7357.1994
PMCID: PMC237177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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