Substrate requirements of hepatitis C virus serine proteinase for intermolecular polypeptide cleavage in Escherichia coli.

doi:10.1128/JVI.68.11.7351-7357.1994

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Article

Substrate requirements of hepatitis C virus serine proteinase for intermolecular polypeptide cleavage in Escherichia coli.

Journal of virology - 1 Nov 1994

Komoda Y, Hijikata M, Sato S, Asabe S, Kimura K, Shimotohno K

Abstract excerpt

Using as substrates a series of chimeric proteins containing various fragments of the hepatitis C virus precursor polyprotein between Escherichia coli maltose binding protein and dihydrofolate reductase, we analyzed the substrate requirements of hepatitis C viral serine proteinase (Cpro-2) for in...

Topics

Amino Acid Sequence
Base Sequence
Escherichia coli
Hepacivirus
Molecular Sequence Data
Mutation
Protein Precursors
Recombinant Fusion Proteins
Serine Endopeptidases
Structure-Activity Relationship

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