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Article

A range of catalytic efficiencies with avian retroviral protease subunits genetically linked to form single polypeptide chains.

The Journal of biological chemistry - 15 Mar 1991

Bizub D, Weber I T, Cameron C E, Leis J P, Skalka A M

Abstract excerpt

Molecular modeling based on the crystal structure of the Rous sarcoma virus (RSV) protease dimer has been used to link the two identical subunits of this enzyme into a functional, single polypeptide chain resembling the nonviral aspartic proteases. Six different linkages were selected to test the importance of different interactions between the amino acids at the amino and carboxyl termini of the two subunits....

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PMID: 1848230

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