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Article

Proteolytic cleavage of wild type and mutants of the F protein of human parainfluenza virus type 3 by two subtilisin-like endoproteases, furin and Kex2.

Journal of virology - 1 Apr 1994

Ortmann D, Ohuchi M, Angliker H, Shaw E, Garten W, Klenk H D

Abstract excerpt

The fusion (F) protein of human parainfluenza virus type 3 contains the tribasic cleavage site R-T-K-R, which was altered by site-directed mutagenesis. Wild-type F protein and various mutants were expressed by recombinant vaccinia viruses. The endogenous endoprotease present in CV-1 cells cleaves F variants containing the furin recognition motif R-X-K/R-R but not variants containing the dibasic site K-R or a...

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Identifiers

PMID: 8139055
DOI: 10.1128/JVI.68.4.2772-2776.1994
PMCID: PMC236759

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Proteolytic cleavage of wild type and mutants of the F protein of human parainfluenza virus type 3 by two subtilisin-like endoproteases, furin and Kex2.PMID 8139055Read ↗

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