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Inducible HEK293 AAV packaging cell lines expressing Rep proteins

15 Jul 2023

Abstract excerpt

Packaging or producer cell lines for scalable recombinant adeno-associated virus (rAAV) production have been notoriously difficult to create due in part to the cytostatic nature of the Rep proteins required for AAV production. The most difficult challenge being creating AAV packaging cell lines using HEK293 parental cells, currently the best mammalian platform for rAAV production due to the constitutive...

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PMID: 37560197
DOI: 10.1016/j.omtm.2023.07.002

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