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Article

Synergistic insertion of two hydrophobic regions drives Sec-independent membrane protein assembly.

The Journal of biological chemistry - 28 Oct 1994

Cao G, Cheng S, Whitley P, von Heijne G, Kuhn A, Dalbey R E

Abstract excerpt

We have studied the membrane insertion of two proteins from the inner membrane of Escherichia coli, both with two transmembrane segments connected by a short periplasmic loop: the M13 procoat protein and a mutant "inverted" leader peptidase. Neither molecule depends on the Sec machinery for inser...

Topics

Bacterial Proteins
Capsid
Capsid Proteins
Cell Membrane
Cell Polarity
Endopeptidases
Escherichia coli
Membrane Proteins
Models, Structural
Mutation
Protein Conformation
Protein Precursors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Serine Endopeptidases

Structure-Activity Relationship

Trypsin

Source

Identifiers

PMID: 7929429

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7929429-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Synergistic insertion of two hydrophobic regions drives Sec-independent membrane protein assembly.PMID 7929429Read ↗

Indecisive M13 procoat protein mutants bind to SecA but do not activate the translocation ATPase.Semantic proximity Read ↗

M13 procoat protein insertion into YidC and SecYEG proteoliposomes and liposomes.Semantic proximity Read ↗

Efficient translocation of positively charged residues of M13 procoat protein across the membrane excludes electrophoresis as the primary force for membrane insertion.Semantic proximity Read ↗

Initial steps in protein membrane insertion. Bacteriophage M13 procoat protein binds to the membrane surface by electrostatic interaction.Semantic proximity Read ↗

Polarity and charge of the periplasmic loop determine the YidC and sec translocase requirement for the M13 procoat lep protein.Semantic proximity Read ↗

Features of membrane protein sequence direct post-translational insertion.Semantic proximity Read ↗

Membrane protein sequence features direct post-translational insertionSemantic proximity Read ↗

Sec dependent and sec independent assembly of E. coli inner membrane proteins: the topological rules depend on chain length.Semantic proximity Read ↗

The translocation of negatively charged residues across the membrane is driven by the electrochemical potential: evidence for an electrophoresis-like membrane transfer mechanism.Semantic proximity Read ↗

The E. coli signal recognition particle is required for the insertion of a subset of inner membrane proteins.Semantic proximity Read ↗

SecA is required for the insertion of inner membrane proteins targeted by the Escherichia coli signal recognition particle.Semantic proximity Read ↗

Real time observation of single membrane protein insertion events by the Escherichia coli insertase YidC.Semantic proximity Read ↗

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