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Article

Indecisive M13 procoat protein mutants bind to SecA but do not activate the translocation ATPase.

The Journal of biological chemistry - 12 Oct 2001

Roos T, Kiefer D, Hugenschmidt S, Economou A, Kuhn A

Abstract excerpt

The M13 procoat protein serves as the paradigm for the Sec-independent membrane insertion pathway. This protein is inserted into the inner membrane of Escherichia coli with two hydrophobic regions and a central periplasmic loop region of 20 amino acid residues. Extension of the periplasmic loop region renders M13 procoat membrane insertion Sec-dependent. Loop regions with 118 or more residues required SecA and...

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Source

Identifiers

PMID: 11487581
DOI: 10.1074/jbc.M105483200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Indecisive M13 procoat protein mutants bind to SecA but do not activate the translocation ATPase.PMID 11487581Read ↗

Synergistic insertion of two hydrophobic regions drives Sec-independent membrane protein assembly.Semantic proximity Read ↗

M13 procoat protein insertion into YidC and SecYEG proteoliposomes and liposomes.Semantic proximity Read ↗

Escherichia coli SecA truncated at its termini is functional and dimeric.Semantic proximity Read ↗

Efficient translocation of positively charged residues of M13 procoat protein across the membrane excludes electrophoresis as the primary force for membrane insertion.Semantic proximity Read ↗

Multiple SecA molecules drive protein translocation across a single translocon with SecG inversion.Semantic proximity Read ↗

Protein translocation functions of Escherichia coli SecY: in vitro characterization of cold-sensitive secY mutants.Semantic proximity Read ↗

Polarity and charge of the periplasmic loop determine the YidC and sec translocase requirement for the M13 procoat lep protein.Semantic proximity Read ↗

The PrlA and PrlG phenotypes are caused by a loosened association among the translocase SecYEG subunits.Semantic proximity Read ↗

SecY and SecA interact to allow SecA insertion and protein translocation across the Escherichia coli plasma membrane.Semantic proximity Read ↗

Roles of the conserved cytoplasmic region and non-conserved carboxy-terminal region of SecE in Escherichia coli protein translocase.Semantic proximity Read ↗

Importance of transmembrane segments in Escherichia coli SecY.Semantic proximity Read ↗

Dynamic action of the Sec machinery during initiation, protein translocation and termination.Semantic proximity Read ↗

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