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Article

Role of homologous ASP334 and GLU319 in human non-gastric H,K- and Na,K-ATPases in cardiac glycoside binding.

Biochemical and biophysical research communications - 27 Apr 2007

Radkov Rossen, Kharoubi-Hess Solange, Schaer Danièle, Modyanov Nikolai N, Geering Käthi, Horisberger Jean-Daniel

Abstract excerpt

Cardiac steroids inhibit Na,K-ATPase and the related non-gastric H,K-ATPase, while they do not interact with gastric H,K-ATPase. Introducing an arginine, the residue present in the gastric H,K-ATPase, in the second extracellular loop at the corresponding position 334 in the human non-gastric H,K-ATPase (D334R mutation) rendered it completely resistant to 2mM ouabain. The corresponding mutation (E319R) in alpha1...

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Identifiers

PMID: 17349614
DOI: 10.1016/j.bbrc.2007.02.119
PMCID: PMC1987332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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