Article
A point mutation of the Na+/H+ exchanger gene (NHE1) and amplification of the mutated allele confer amiloride resistance upon chronic acidosis.
Proceedings of the National Academy of Sciences of the United States of America - 15 May 1993
Counillon L, Franchi A, Pouysségur J
Abstract excerpt
The diuretic drug amiloride and its 5-amino substitute N5-methyl-N5-propylamiloride (MPA) are potent inhibitors of the growth factor-activatable Na+/H+ exchanger isoform 1 (NHE1). This inhibitor competes with Na+, presumably by interacting with the ion-transport site of the NHE molecule. As an ap...
Topics
- Alleles
- Amiloride
- Amino Acid Sequence
- Animals
- Biological Transport
- Carrier Proteins
- Cells, Cultured
- Cloning, Molecular
- Cricetinae
- Cricetulus
- Drug Resistance
- Hydrogen-Ion Concentration
- In Vitro Techniques
- Membrane Proteins
- Molecular Sequence Data
- Point Mutation
- Recombinant Fusion Proteins
- Restriction Mapping