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Article

A point mutation of the Na+/H+ exchanger gene (NHE1) and amplification of the mutated allele confer amiloride resistance upon chronic acidosis.

Proceedings of the National Academy of Sciences of the United States of America - 15 May 1993

Counillon L, Franchi A, Pouysségur J

Abstract excerpt

The diuretic drug amiloride and its 5-amino substitute N5-methyl-N5-propylamiloride (MPA) are potent inhibitors of the growth factor-activatable Na+/H+ exchanger isoform 1 (NHE1). This inhibitor competes with Na+, presumably by interacting with the ion-transport site of the NHE molecule. As an approach to identify this site, we previously reported the use of a specific H(+)-killing selection technique for...

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Identifiers

PMID: 8389452
DOI: 10.1073/pnas.90.10.4508
PMCID: PMC46541

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A point mutation of the Na+/H+ exchanger gene (NHE1) and amplification of the mutated allele confer amiloride resistance upon chronic acidosis.PMID 8389452Read ↗

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