Mutants of Streptomyces cattleya defective in the synthesis of a factor required for thienamycin production.

doi:10.7164/antibiotics.47.992

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Article

Mutants of Streptomyces cattleya defective in the synthesis of a factor required for thienamycin production.

The Journal of antibiotics - 1 Sept 1994

Buchan T, Roach C, Ruby C, Taylor D, Preisig C, Reeves C

Abstract excerpt

Thienamycin non-producing mutants of Streptomydes cattleya were identified that displayed a cross-feeding relationship. A diffusible product from one of these mutants (RK-11) resulted in restoration of thienamycin production when fed to cultures of another mutant (RK-4). In vivo radiolabeling exp...

Topics

Chromatography, High Pressure Liquid
Cystine
Ethyl Methanesulfonate
Hydrogen-Ion Concentration
Methionine
Mutation
Streptomyces
Sulfur Radioisotopes
Temperature
Thienamycins
Tritium

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