Article
Mutants of Streptomyces cattleya defective in the synthesis of a factor required for thienamycin production.
The Journal of antibiotics - 1 Sept 1994
Buchan T, Roach C, Ruby C, Taylor D, Preisig C, Reeves C
Abstract excerpt
Thienamycin non-producing mutants of Streptomydes cattleya were identified that displayed a cross-feeding relationship. A diffusible product from one of these mutants (RK-11) resulted in restoration of thienamycin production when fed to cultures of another mutant (RK-4). In vivo radiolabeling experiments were conducted to test whether the RK-11 mutant produced a late biosynthetic intermediate which contained a...
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