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Insights into fluorometabolite biosynthesis in Streptomyces cattleya DSM46488 through genome sequence and knockout mutants.

Bioorganic chemistry - 1 Oct 2012

Zhao Chunhua, Li Peng, Deng Zixin, Ou Hong-Yu, McGlinchey Ryan P, O'Hagan David

Abstract excerpt

Streptomyces cattleya DSM 46488 is unusual in its ability to biosynthesise fluorine containing natural products, where it can produce fluoroacetate and 4-fluorothreonine. The individual enzymes involved in fluorometabolite biosynthesis have already been demonstrated in in vitro investigations. Candidate genes for the individual biosynthetic steps were located from recent genome sequences. In vivo inactivation of...

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PMID: 22858315
DOI: 10.1016/j.bioorg.2012.06.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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