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Article

Interleukin 1 receptor antagonist gene polymorphism association with lichen sclerosus.

Human genetics - 1 Oct 1994

Clay F E, Cork M J, Tarlow J K, Blakemore A I, Harrington C I, Lewis F, Duff G W

Abstract excerpt

Cytokines play key roles in immune responses, inflammation and fibrosis. The balance between levels of cytokines, their receptors and specific inhibitors controls inflammatory reactions in tissues. The pathogenesis of lichen sclerosus is unknown but probably involves cytokine mediators such as interleukin 1 (IL-1) and interleukin 1 receptor antagonist (IL-1ra). The IL-1ra is a competitive inhibitor of IL-1 alpha...

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PMID: 7927338
DOI: 10.1007/BF00201602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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