Article
Interleukin 1 receptor antagonist gene polymorphism association with lichen sclerosus.
Human genetics - 1 Oct 1994
Clay F E, Cork M J, Tarlow J K, Blakemore A I, Harrington C I, Lewis F, Duff G W
Abstract excerpt
Cytokines play key roles in immune responses, inflammation and fibrosis. The balance between levels of cytokines, their receptors and specific inhibitors controls inflammatory reactions in tissues. The pathogenesis of lichen sclerosus is unknown but probably involves cytokine mediators such as interleukin 1 (IL-1) and interleukin 1 receptor antagonist (IL-1ra). The IL-1ra is a competitive inhibitor of IL-1 alpha...
Topics
- Alleles
- Base Sequence
- Female
- Gene Frequency
- Genotype
- Humans
- Interleukin 1 Receptor Antagonist Protein
- Lichen Sclerosus et Atrophicus
- Male
- Molecular Sequence Data
- Polymorphism, Genetic