Interleukin-1 receptor antagonist gene polymorphism in patients with rheumatoid arthritis in India.

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Article

Interleukin-1 receptor antagonist gene polymorphism in patients with rheumatoid arthritis in India.

The Indian journal of medical research - 1 Jun 2006

Grover S, Tandon S, Misra R, Aggarwal A

Abstract excerpt

BACKGROUND & OBJECTIVES: Interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring anti-inflammatory molecule that blocks action of IL-1. Polymorphism in IL-1Ra gene intron 2 results in differences in production of IL-1Ra. These polymorphisms are reportedly associated with autoimmune disease susceptibility in different studies. However, such data are lacking from India. We undertook this study to...

Topics

Arthritis, Rheumatoid
DNA Primers
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
India
Interleukin 1 Receptor Antagonist Protein
Male
Polymorphism, Genetic

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Open in PubMed

Identifiers

PMID: 16885604

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