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Article

IL-1 receptor antagonist gene polymorphism in recurrent spontaneous abortion.

Journal of reproductive immunology - 1 Feb 2003

Karhukorpi Jari, Laitinen Tarja, Kivelä Helena, Tiilikainen Anja, Hurme Mikko

Abstract excerpt

Genetic factors may contribute to the development of an aberrant pro-inflammatory immune response during pregnancy, thereby increasing the risk of some pregnancy-related pathologies such as recurrent spontaneous abortion (RSA). Interleukin 1 receptor antagonist is an important anti-inflammatory molecule encoded by the IL1RN gene, in which an intronic polymorphism has been described. Even though the molecular...

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PMID: 12609525
DOI: 10.1016/s0165-0378(02)00044-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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