Conversion of a mesodermalizing molecule, the Xenopus Brachyury gene, into a neuralizing factor.

doi:10.1101/gad.8.8.939

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Article

Conversion of a mesodermalizing molecule, the Xenopus Brachyury gene, into a neuralizing factor.

Genes & development - 15 Apr 1994

Rao Y

Abstract excerpt

It has been shown previously that a Xenopus homolog of the mouse gene Brachyury, Xbra, can initiate mesodermal differentiation. Here, I report that a Xbra mutant truncated at the carboxyl terminus, B304, has lost the mesodermalizing activity and can block the activity of the wild-type Xbra. Injection of B304 mRNA led to formation of neural structures in animal cap explants. Examination of molecular markers in...

Topics

Activins
Animals
Base Sequence
Biomarkers
Cell Adhesion Molecules, Neuronal
Cell Differentiation
DNA-Binding Proteins
Fetal Proteins
Fibroblast Growth Factor 2
Follistatin
Forkhead Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glycoproteins

Inhibins

Mesoderm

Molecular Sequence Data

Mutation

Nervous System

Nuclear Proteins

Source

Open in PubMed

Identifiers

PMID: 7926778
DOI: 10.1101/gad.8.8.939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7926778-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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