Article
Functional analysis of phosphorylation sites in human lamin A controlling lamin disassembly, nuclear transport and assembly.
European journal of cell biology - 1 Dec 1993
Haas M, Jost E
Abstract excerpt
We have constructed point mutations in human lamin A cDNA at conserved serine and threonine residues, some of which were shown to be phosphorylated in vitro by cdc2-kinase and protein kinase C and in vivo. Using a functional in vivo assay system, we identified three categories of mutant phenotype...
Topics
- Amino Acid Sequence
- Animals
- Biological Transport
- Cell Line
- Cell Nucleus
- Chick Embryo
- DNA
- Fluorescent Antibody Technique
- Humans
- Lamin Type A
- Lamins
- Mitosis
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Phenotype
- Phosphorylation
- Protein Kinase C