Article
Protein Kinase C Alpha Cellular Distribution, Activity, and Proximity with Lamin A/C in Striated Muscle Laminopathies.
Cells - 31 Oct 2020
Nicolas Hannah A, Bertrand Anne T, Labib Sarah, Mohamed-Uvaize Musfira, Bolongo Pierrette M, Wu Wen Yu, Bilińska Zofia T, Bonne Gisèle, Akimenko Marie-Andrée, Tesson Frédérique
Abstract excerpt
Striated muscle laminopathies are cardiac and skeletal muscle conditions caused by mutations in the lamin A/C gene (LMNA). LMNA codes for the A-type lamins, which are nuclear intermediate filaments that maintain the nuclear structure and nuclear processes such as gene expression. Protein kinase C alpha (PKC-α) interacts with lamin A/C and with several lamin A/C partners involved in striated muscle laminopathies....
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