Article
A phosphorylation cluster in the chromatin-binding region regulates chromosome association of LAP2alpha.
The Journal of biological chemistry - 20 Aug 2004
Gajewski Andreas, Csaszar Edina, Foisner Roland
Abstract excerpt
LAP2alpha is a LEM family protein associated with nucleoplasmic A-type lamins and chromatin in interphase. Like lamins and other lamina proteins LAP2alpha is cytoplasmic in metaphase, but it associates with chromosomes prior to nuclear envelope formation in late anaphase to telophase. In vitro phosphorylation analysis and mass spectrometry identified a cluster of at least three mitotic cyclin-dependent kinase 1...
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