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Article

Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria.

The EMBO journal - 15 Jul 1998

Triglia T, Wang P, Sims P F, Hyde J E, Cowman A F

Abstract excerpt

We have exploited the recently developed ability to trans- fect the malaria parasite Plasmodium falciparum to investigate the role of polymorphisms in the enzyme dihydropteroate synthase (DHPS), identified in sulfadoxine-resistant field isolates. By using a truncated form of the dhps gene, specif...

Topics

Alleles
Animals
Antimalarials
DNA, Protozoan
Dihydropteroate Synthase
Drug Resistance
Genes, Protozoan
Mutagenesis
Mutation
Plasmodium falciparum
Polyploidy
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Protozoan

Recombination, Genetic

Sulfadoxine

Source

Open in PubMed Open full text

Identifiers

PMID: 9669998
DOI: 10.1093/emboj/17.14.3807
PMCID: PMC1170716

Genes

DHPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9669998-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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