Article
A mutation-specific PCR system to detect sequence variation in the dihydropteroate synthetase gene of Plasmodium falciparum.
Molecular and biochemical parasitology - 1 Apr 1995
Wang P, Brooks D R, Sims P F, Hyde J E
Abstract excerpt
Sulphur-based antimalarial drugs targeted at dihydropteroate synthetase (DHPS) are frequently used in synergistic combination with inhibitors of dihydrofolate reductase (DHFR) to combat chloroquine-resistant malaria. We have previously shown that lines of Plasmodium falciparum resistant to the mo...
Topics
- Alleles
- Animals
- Base Sequence
- DNA Mutational Analysis
- Dihydropteroate Synthase
- Drug Resistance
- Genes, Protozoan
- Genetic Variation
- Molecular Sequence Data
- Plasmodium falciparum
- Point Mutation
- Polymerase Chain Reaction
- Sulfadoxine