Article
Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum.
Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 1997
Triglia T, Menting J G, Wilson C, Cowman A F
Abstract excerpt
Plasmodium falciparum causes the most severe form of malaria in humans. An important class of drugs in malaria treatment is the sulfone/sulfonamide group, of which sulfadoxine is the most commonly used. The target of sulfadoxine is the enzyme dihydropteroate synthase (DHPS), and sequencing of the...
Topics
- Animals
- Antimalarials
- Base Sequence
- DNA, Protozoan
- Dihydropteroate Synthase
- Drug Resistance
- Enzyme Inhibitors
- Escherichia coli
- Humans
- Kinetics
- Multienzyme Complexes
- Mutation
- Plasmodium falciparum
- Sulfadoxine
- Sulfonamides
- Sulfones