State of the p53 gene in hepatocellular carcinomas of ground squirrels and woodchucks with past and ongoing infection with hepadnaviruses.

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Article

State of the p53 gene in hepatocellular carcinomas of ground squirrels and woodchucks with past and ongoing infection with hepadnaviruses.

Cancer research - 15 Oct 1994

Rivkina M B, Cullen J M, Robinson W S, Marion P L

Abstract excerpt

Infection with hepadnaviruses and exposure to dietary aflatoxin are considered major risk factors in the development of hepatocellular carcinoma (HCC) both in humans and in animals. Recently, a broad range of mutations in the p53 tumor suppressor gene has been reported in human HCCs, predominantl...

Topics

Aflatoxin B1
Amino Acid Sequence
Animals
Base Sequence
Blotting, Southern
Carcinoma, Hepatocellular
DNA, Complementary
Genes, p53
Hepadnaviridae Infections
Hepatitis B
Hepatitis B Virus, Woodchuck
Hepatitis, Viral, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Marmota

Molecular Sequence Data

Mutation

Orthohepadnavirus

Sciuridae

Species Specificity

Source

Open in PubMed

Identifiers

PMID: 7923176

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7923176-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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