Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites: absence of mutation prescribing the phenotype in the CYP1A2 gene.

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Article

Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites: absence of mutation prescribing the phenotype in the CYP1A2 gene.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2000

Nakajima M, Yokoi T, Mizutani M, Shin S, Kadlubar F F, Kamataki T

Abstract excerpt

Caffeine has been used as a metabolic probe to determine the relative levels of CYP1A2 activity in different individuals, since this compound is specifically 3-demethylated by CYP1A2. Urine specimen obtained at a 4-5-h interval after caffeine ingestion from 205 Japanese were analyzed using the [1...

Topics

Adolescent
Adult
Aged
Base Sequence
Caffeine
Child
Cytochrome P-450 CYP1A2
Cytochrome P-450 Enzyme System
DNA
Female
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Japan

Male

Middle Aged

Molecular Sequence Data

Mutation

Oxidoreductases

Pedigree

Source

Open in PubMed

Identifiers

PMID: 7920209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7920209-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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