Article
Single-molecule analysis of chemotactic signaling in Dictyostelium cells.
Science (New York, N.Y.) - 26 Oct 2001
Ueda M, Sako Y, Tanaka T, Devreotes P, Yanagida T
Abstract excerpt
Single-molecule imaging techniques were used to reveal the binding of individual cyclic adenosine 3',5'-monophosphate molecules to heterotrimeric guanine nucleotide-binding protein coupled receptors on the surface of living Dictyostelium discoideum cells. The binding sites were uniformly distributed and diffused rapidly in the plane of the membrane. The probabilities of individual association and dissociation...
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