Concomitant loss of transforming growth factor (TGF)-beta receptor types I and II in TGF-beta-resistant cell mutants implicates both receptor types in signal transduction.

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Article

Concomitant loss of transforming growth factor (TGF)-beta receptor types I and II in TGF-beta-resistant cell mutants implicates both receptor types in signal transduction.

The Journal of biological chemistry - 25 Oct 1990

Laiho M, Weis M B, Massagué J

Abstract excerpt

A panel of 71 chemically mutagenized Mv1Lu mink lung epithelial cell clones were selected based on their resistance to the growth inhibitory action of transforming growth factor beta 1 (TGF-beta 1) and TGF-beta 2. Characterization of TGF-beta receptors in these mutants indicates that the TGF-beta...

Topics

Affinity Labels
Animals
Cell Line
Clone Cells
Mink
Mutation
Receptors, Cell Surface
Receptors, Transforming Growth Factor beta
Signal Transduction
Transforming Growth Factor beta

Source

Open in PubMed

Identifiers

PMID: 2170414

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2170414-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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