Article
The activity of a designer tissue inhibitor of metalloproteinases (TIMP)-1 against native membrane type 1 matrix metalloproteinase (MT1-MMP) in a cell-based environment.
Cancer letters - 1 Apr 2010
Lee Meng-Huee, Atkinson Susan, Rapti Magdalini, Handsley Madeleine, Curry Valerie, Edwards Dylan, Murphy Gillian
Abstract excerpt
The surface-anchored membrane type 1 matrix metalloproteinase (MT1-MMP) degrades a wide range of extracellular matrix components that includes collagens, laminins, fibronectin and the structural proteoglycan aggrecan. The enzyme modulates cell motility and plays an important role in tumour invasion and proliferation. We have previously designed a variant of tissue inhibitor of metalloproteinase (TIMP)-1 bearing a...
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