Platelet factor 4 gene expression in a human megakaryocytic leukemia cell line (CMK) and its differentiated subclone (CMK11-5).

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Article

Platelet factor 4 gene expression in a human megakaryocytic leukemia cell line (CMK) and its differentiated subclone (CMK11-5).

Experimental hematology - 1 Oct 1991

Adachi M, Ryo R, Sato T, Yamaguchi N

Abstract excerpt

The human cell line CMK spontaneously expresses megakaryocytic characteristics and can be induced to differentiate into mature megakaryocytes after exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA). In comparison with CMK, we have examined the characteristics of a subclone, designated as CMK...

Topics

Blotting, Northern
Cell Differentiation
Gene Expression Regulation, Leukemic
Humans
Leukemia, Megakaryoblastic, Acute
Megakaryocytes
Phenotype
Platelet Factor 4
RNA, Messenger
Tetradecanoylphorbol Acetate
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1893970

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1893970-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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